Autoimmune cytopenias in inborn errors of immunity: associations with monogenic mutations and immunologic parameters
AICs represent a significant clinical burden in adult IEIs and may occur in association with a wide range of genetic variants. Class-switched memory B cells (CD27⁺IgD⁻) percentages, CD4⁺/CD8⁺ T-cell ratio, and baseline IgG were not significantly associated with autoimmunity in this cohort. These findings underscore the need for broader immunophenotypic and genetic screening to improve the early recognition and management of autoimmune complications in IEIs.
Authors
- Seçim Kolak (ORCID: https://orcid.org/0000-0002-5406-3459)
- Şevket Arslan (ORCID: https://orcid.org/0000-0002-0343-0159)
- Eloise Harman (ORCID: https://orcid.org/0000-0002-1554-0419)
- Fatih Çölkesen (ORCID: https://orcid.org/0000-0002-6595-1267)
- Mehmet Emin Gerek (ORCID: https://orcid.org/0000-0003-4792-0544)
- Ferhat Sağun (ORCID: https://orcid.org/0000-0003-3752-8469)
- Şükran Aslan Savaş
Institutions
- Necmettin Erbakan University (TR)
Publication Details
- Journal
- BMC Immunology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12865-025-00752-1
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Necmettin Erbakan Üniversitesi