Distinct Pathogenic Mechanisms of Neurodegeneration in Pachychoroid Pigment Epitheliopathy Versus Intermediate Age-Related Macular Degeneration
Two distinct pathways cause neurodegeneration: compressive (PPE: choroidal thickening → choriocapillaris compression → neurodegeneration) and ischemic (AMD: choroidal thinning → hypoperfusion → neurodegeneration).
Authors
- Federica Evangelista (ORCID: https://orcid.org/0000-0003-3781-8124)
- Massimo Carella (ORCID: https://orcid.org/0000-0002-6830-6829)
- Silvana De Leonardis
- Pasquale Viggiano (ORCID: https://orcid.org/0000-0002-0323-967X)
- Francesco Boscia (ORCID: https://orcid.org/0000-0002-5478-060X)
- Lorenzo Accurso Tagano
- Roberta Binetti
- S. E. Dore (ORCID: https://orcid.org/0000-0001-6439-8028)
- Maria Grazia Pignataro
- Giovanni Alessio
- Cristiana Iaculli (ORCID: https://orcid.org/0000-0003-0078-6480)
- Alba Chiara Termite
- Paolo Evangelista
- Giulia Ribezzi
Institutions
- University of Foggia (IT)
- University of Sassari (IT)
- El.En. Group (Italy) (IT)
- Comelz (Italy) (IT)
- University of Bari Aldo Moro (IT)
- European Institute of Oncology (IT)
Publication Details
- Journal
- Ophthalmology and Therapy
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1007/s40123-025-01246-4
- Citations
- 2
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.41