Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-Lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort

ECG abnormalities, including those reflecting CAN, are common in individuals with T2D <10 years and more so in those with certain cardiovascular risk factors. The development of major ECG abnormalities may be lower with liraglutide.

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Journal
Diabetes Care
Published
2025-09-23
DOI
https://doi.org/10.2337/dc25-1087
Primary Topic
Heart Rate Variability and Autonomic Control
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article
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article

Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-Lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort

Shihchen Kuo, Mary Beth Vonder Meulen, S. Tanukonda, C.J. Buys et al.
Diabetes Care
Heart Rate Variability and Autonomic Control
article

Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-Lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort

Shihchen Kuo, Mary Beth Vonder Meulen, S. Tanukonda, C.J. Buys, D. Gabrielson, S. E. Inzucchi, E. LaSalle, Tom A. Elasy, Peter W.F. Wilson, Andrew A. Bremer, S. Fortmann, M. Coe, J. Eggert, E. Duran-Valdez, Mark Rogge, V. Lagari-Libhaber, J. Costello, Amerta Ghosh, Tessa Concepcion, M. Pavlionis, Kristina M. Utzschneider, A. L. Cherrington, D.H. Josephson, Valerie Arends, L. Alarcon-Casas Wright, Emily B. Schroeder, Steven L. Kunkel, Silvio E. Inzucchi, S. Behringer-Massera, J. F. Largay, Vanita R. Aroda, M. Herson, L. Morton, S. Hensley, A. Kozedub, S. Coffer, D. Sanchez, Anders L. Carlson, E. Schield, Michael W. Hamm, T. Hamilton, Victoria Jenkins, B. Gulanski, M. Hillard, K. Tsingine, E. Debnam, E. Gonzalez Hattery, Naji Younes, C. Hazlett, Ken Resnicow, Dace Trence, J. Prihoda, O. Griffith, F. Ali Jamaleddin Ahmad, M. Matwichyna, P. Kringas, B. Morales Gomez, Aimee Katona, Santiago Durán, Jean M. Dostou, T. Karshner, Lisa Keasler, Jill P. Crandall, Rajesh Garg, B. Gildersleeve, A. Lteif, J. Brown-Friday, Philip Raskin, G. Lord, C. Sprague, N. Kessler, Meng H. Tan, M.R. Gramzinski, E. Panos, A. Jackson, T. Conner, Jesse C. Seegmiller, K. Lessard, A. Saenger, Jennifer B. Green, H. Liu, C. Jensen, Rodica Pop‐Busui, Daniel S. Hsia, T. Kue Young, R. Kochis, L. Iannone, J. Hyatt, P.A. Ramey, J. Gluth, N. Rasouli, V. Ripley, H. Estrella, J. Cuffee, Corey Lyon, Lesia Lesne, Dong Joon Min, Ionut Bebu, Jeanine Albu, A. Bancroft, S. Burbach, K. Berame, C. Underkofler, J. Adducci, Maria V. Kononets, E. Mesimer, A. Arey, Arun Alfred, Margaret Tiktin, C. Adams, M. Sibymon, Jonathan Krakoff, Rosa Irene Garza, B. Torgrimson-Ojerio, Charles Baker, R. Nieto-Martinez, A. Bantle, H. Schneier, Christine Stevens, J. Bethepu, K. Schell, Curtiss Puckett, Anne M. Fagan, F. Xavier Pi‐Sunyer, Mary Larkin, Tú-Anh Tran, L. Shackelford, A.K. Riccio Veliz, R.R. Ishii, Christian Lund, L. Holloway, N. Prikhodko, Alexander Kuhn, C. Hausheer, Ruchi Gaba, Olga Sánchez, M. Tiktin, Sandra Kissel, J. Pring, A. Ressing, A. Thomassie, Harry Glauber, A. Adolphe, L. Colosimo, A. Waltje, Carol Recklein, A. Ideozu, Marc D. McKee, Hiba Abou Assi, Judith Fradkin, W. Tamborlane, Henrique A. Almeida, V. Morimoto, Basma N. Fattaleh, Kennedy C. Whitley, M. Jackson, D. S. Schade, William I. Sivitz, K. Bays, Jennifer B. Marks, Elizabeth Legowski, Аліна Гончарова, D. Ghioni, Richard M. Bergenstal, H. Verastiqui, Ross M. Fraser, E. Xhori, James B. Meigs, S. McCullars, J. Craig, L. Oropesa-Gonzalez, K. Josey, M.C.R. Lawson, L. Osornio Walker, John M. Lachin, M. Alguard, K. Kleeberger, J. Lipps Hogan, Shannon D. Smith, C. Friason, L. Savoye, L. Sayyed Kassem, R. Pop-Busui, D. Sturgess, J.B. Kimpel, Kimberly Martin, C. DeLue, W. Timothy Garvey, D. Howard, Jingzhou Hu, L. Goodhall, Adam D. Maxwell, SA Khan, John B. Buse, D. Aguillar, Hermes Flórez, J. Iacoboni, R. Nelson, Mehdi Razzaghi, Juan Tejada, A. Montosa, Nicole M. Butera, Oliver Smith, Mark R. Burge, Lindsay N. Alfano, John Day, M. Mech, S. Maggs, Lisa Tucker, L.K. Knosp, R. Eggleston, S. Guarda, K. Kersey, Denelle Martin, H. Petrovitch, V. Perez-Rosas, James E. Boers, S. Boeder, Tao L. Lowe, L. Kiker, L. Gurry, B.M. Satterwhite, Kimani A. Stancil, N. Haynes, Jennifer Cook, T. Schweiger, Jeremy Pettus, E. Magenheimer, David S. Schade, J. Leger, Nathaniel C. Cady, R. Passi, J. Lukin, Suzanne Morton, Elsayed Z. Soliman, Manuel Yepes, J. Huminik, N. Rassouli, Stephen D. Hall, B. Hollis, Michelle L. Curtis, Priscilla Hollander, S. Sahnow, Tasha Stephanie Raines, R. Puttnam, S. Sao, B. Veciana, Janet B. McGill, Louis Hue, G. Fry, Andrew Camp, B. Ojoawo, B. Redmon, A. Dragg, R. Lorch, Cary N. Mariash, Haisam Ismail, F. Morehead, C. Sanders, K. Gumpel, Elizabeth Burgess, Elizabeth Ellis, Jean Martínez, J. English Jones, F. Ismail-Beigi, F. Joarder, Y.J. Kendal, M. Sue Kirkman, R.B. Kreymer, Elizabeth G. Raymond, Suzi Jones, P. Kirchhoff, T. Kulow, D. Culmer, Mark W. Johnson, Laura Young, D. Hernandez McGinnis, Henry B. Burch, C. Waguespack, Merrick L. Furst, Ranee Chatterjee, Sara Douglass, Kieren J. Mather, A. Cuadot, C. Suratt, M. Gutt, J. Bastawrose, Samuel P. Rosin, Sharina D. Person, K. Ballentine-Cargill, A. Dushkin, E. King, A. Taddese, Chandni Patel, Z. El-Haqq, Stephanie Assuras, A. Balasubramanyam, R. Mungara, Christopher L. Newman, Lawrence S. Phillips, Z. M. Zhang, A. Goley, A. Loveland, Jamie Diner, S. Rhothisen, Choong Kyun Rhee, S. Machineni, K. Arnold, Melissa G.Y. Lee, Edward J. Boyko, Barbara Steiner, V. Shivaswamy, A. DeManbey, L. Broadwater, A. Kirpitch, K. Chionh, Thomas Martens, Heidi Krause‐Steinrauf, Werner Aberer, S. Mudaliar, L. Schnurr-Breen, E. R. Seaquist, Adline Ghazi, Mattias Backman, Maria Daniela Hurtado, C. Sanders-Jones, E. Scripsick, E. Joshevama, A. Scrymgeour, W. Ye, John Kerr, C. Falck-Ytter, M. Abdul-Ghani, Alyson Ross, H. AbouAssi, A. Ahmann, L. L. Thomas, J. Criscola, Robert E. Henry, L. Kuechenmeister, N. Thangthaeng, V. Pirics, F. Sakha, T. Onadeko, G. McPhee, N.O. Bermudez, L. Manandhar, Ralph A. DeFronzo, Aleksandra Król, Caroline Wright, Sabina Casula, C. Moak, P. Burt, R. Tillson, Daisuke Yamashita, Robin Goland, Y. Li, K. Bergamo, Deborah J. Wexler, Cyrus Desouza, S. Frances, A. Zamorano, S. Gonzalez de la torre, С. А. Назаров, B. Pucchetti, Eugênio Cersósimo, Hui Shao, M. Madden, A. Agne, Tina Killean, D. Garcia-Acosta, J. Luchsinger, Erik J. Groessl, Frank L. Greenway, Rosa María Ayala, William T. Cefalu, T. Harindhanavudhi, Jaebum Park, H. Krause-Steinrauf, C. R. Lovell, Michelle Magee, Rada Mihalcea, Mary Jane Clifton, Kon Chu, P. McGee, M. Cayford, M. Mullen, Sophia H. Hox, D. Aby-Daniel, Christopher S. Carlson, Curtis Triplitt, R. Hill, G. Rocchio, Kathryn Burton, J. B. Green, M.M. Mishko, J. Arceneaux, Susanne Steiner, Debra S. Dyer, S. Bule, Christine A. White, C. Campbell, H. Willis, K. Mularski, J. Barzilay, Yashashwi Pokharel, N. Rivera-Eschright, S. Bojescu, M. Maher-Albertelli, Mary Ann Banerji, Sunder Mudaliar, Salvador Hernández, Elizabeth R. Seaquist, G. Riera, R. Goidel, C. Gullett, Joseph R. McConnell, W. Konerza, Willy Marcos Valencia, K. Stokes, F. Mwicigi, Ping Zhang, A. K. Sood, Nicholas M. Brown, Anjali Kumar, K. Pham, Yuan Gao, Xiuqun Gong, Guillermo Montes, Elham Kazemi, Michael W. Steffes, David M. Nathan, Manuel García Rodríguez, Moo‐Yong Rhee, Lisa A. Prosser, Mark Tripputi, Jeffrey M. Curtis, E. Diaz, Benjamin Bourgeois, Stephen D. Hurt, P. Gatcomb, B. Chambers, András Katona, H. Dulin, Brenda K. Montgomery, E. Castro, M. Tsovian, John P. Bantle, A. Stallings, Charlton Wilson, L. Estrada, M.J. Rubio Pérez, W. Taylor, Mohammed Khalid, C. Maggio, D. Juarez, Lisa Ngo, Stuart Warren, B. Cramer, Catherine L. Martin, R Peñaloza, W. H. Herman, Connie R. Thacker, Marlo H. Jacobson, Ken Atkinson, S. Lipp, A. Kolli, L.F. Jordan, H. Chong, A. Smiley, John Myers, Daniel Lorber, C. Adkins, K. Wright, S. Yang, A. Cherian, G. Fuller, Susan C. Abraham, Mark N. Feinglos, Darin E. Olson, K. Seipel, S. Martin, M. Salam, E. Cline, Abelardo Morales, Esther Roé, Phyllis August, Robert M. Cohen, Ronna P. Zimmer, N. Hinkle, S. Trikudanathan, N. Patel, B. Ash, B. Kauffman, Emily Tsai
article en

Abstract

ECG abnormalities, including those reflecting CAN, are common in individuals with T2D <10 years and more so in those with certain cardiovascular risk factors. The development of major ECG abnormalities may be lower with liraglutide.

Diabetes CareVol. 48(11)
University of Minnesota (US), Milken Institute (US), University of Miami (US), University of San Diego (US), Oregon Health & Science University (US), University of New Mexico (US), Duke University (US), George Washington University (US), Washington University in St. Louis (US), Yale University (US), University of California San Diego (US), Clinical Research Institute (US), VA San Diego Healthcare System (US), Michigan Medicine (US), Duke Medical Center (US), VA Northeast Ohio Healthcare System (US), Duke University Hospital (US), Wake Forest University (US), Case Western Reserve University (US)
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