An Important Feature of Gastric Adenocarcinoma: Heterogeneous Microsatellite Status
Mismatch repair (MMR) genes play a central role in correcting errors that arise during DNA replication.Gastric adenocarcinomas (GA) with high microsatellite instability (MSI-H) are characterized by deficient MMR (dMMR) machinery, resulting in a hypermutator phenotype.MSI-H cancers exhibit up to a 1000-fold increase in missense mutations compared with microsatellite-stable (MSS) malignancies.
Authors
- Arda Ulaş Mutlu (ORCID: https://orcid.org/0000-0001-7499-7155)
- Erman Aytaç (ORCID: https://orcid.org/0000-0002-8803-0874)
- Rukiye Derin Atabey (ORCID: https://orcid.org/0000-0003-1058-5527)
- Mırac Ajredini (ORCID: https://orcid.org/0000-0002-6795-2351)
- Sibel Erdamar Çetin (ORCID: https://orcid.org/0000-0001-7470-8835)
- Leyla Özer (ORCID: https://orcid.org/0000-0003-4092-5051)
Institutions
- Acıbadem University Atakent Hospital (TR)
Publication Details
- Journal
- Balkan Medical Journal
- Published
- 2025-09-24
- DOI
- https://doi.org/10.4274/balkanmedj.galenos.2025.2025-7-281
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00