Assessment of Some Biochemical Markers In Patients with Beta Thalassemia Major

Abstract Background: The hereditary state red blood cells are harmed by beta-thalassemia's poor hemoglobin (Hb) production. A reduced capacity to synthesis one or more globin chains is its defining feature. For patients with this illness to survive, multiple blood transfusions are necessary. Objective: to examine serum level of serum lipid profiles (Total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low-density lipoprotein (VLDL. Materials and Methods: forty-five patients with β-thalassemia major and forty-five healthy control groups were involved in the present study. Serum lipid profile level in addition to BMI and CRP for both patient and control groups were measured. Results: Serum TC, HDL-C, LDL-C and BMI revealed significant decreasing in patients with β-thalassemia major as comparing with healthy subjects. The findings of TC, HDL-C, LDL-C and BMI which exhibited through this study are, (117.14 ± 14.22 vs 87.26 ± 11.85, P< 0.001), (25.09 ± 2.96 vs 32.15 ± 6.92, P< 0.001), (66.39 ± 14.83 vs 86.13 ± 19.57, P< 0.001) and (19.32 ± 3.26 vs 22.52 ± 3.61, P< 0.001) respectively. Serum level of TG, VLDL-C and CRP manifested significant higher in patients than in healthy subjects. Conclusion: In the current study, TC, HDL-C, LDL-C and BMI revealed significant decreasing in patients with β-thalassemia major as comparing with healthy subjects while Serum level of TG, VLDL-C and CRP manifested significant higher in patients than healthy subjects