Sustainable Multicomponent Synthesis of Benzoxazoles from Alcohols and Aldehydes Catalyzed by Copper Catalysts

Abstract Cu(II) complexes were synthesized via intramolecular hydroxylation utilizing hydrogen peroxide, mimicking the structure and action of the catechol oxidase enzyme. Utilizing these complexes, multicomponent reaction was established to produce benzoxazole derivatives. This reaction involved the combination of catechol with either an aldehyde or alcohol in the presence of ammonium acetate, serving as the nitrogen provider. Multiple control experiments were conducted to clarify the underlying mechanism. The utility of this approach was showcased through the large‐scale synthesis of several benzoxazole derivatives.