Literature update and MRI case collection of unusual localizations

Endometriosis affects approximately 10% of women of reproductive age and is a significant cause of pelvic pain and infertility. It manifests in three patterns: superficial peritoneal lesions, ovarian endometriomas, and deep infiltrating endometriosis (DIE). Our aim is to remind radiologists of the possibility of atypical locations of pelvic and extrapelvic endometriosis and to illustrate their characteristics on magnetic resonance imaging (MRI). The most common site of endometriosis is the ovaries, followed by the pelvic peritoneum. Less common locations include deep subperitoneal tissues, the gastrointestinal tract, the bladder, the thorax, and subcutaneous tissues. We present three rare clinical cases: diaphragmatic endometriosis, inguinal canal endometriosis, and a case of sciatic nerve infiltration. MRI provides important findings that help classify the disease and identify the extent of the lesion, thus facilitating appropriate diagnosis and treatment. Radiologists should be familiar with the MRI findings of DIE in various anatomical sites to provide information that allows for adequate pre-surgical counseling.

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Publication Details

Journal
Discover Medicine
Published
2025-09-24
DOI
https://doi.org/10.1007/s44337-025-00429-z
Primary Topic
Endometriosis Research and Treatment
Type
article
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article

Literature update and MRI case collection of unusual localizations

Flavia Rufi, Guglielmo Manenti, Francesca Montesanto, Mario Laudazi et al.
Discover Medicine
Endometriosis Research and Treatment
article

Literature update and MRI case collection of unusual localizations

Flavia Rufi, Guglielmo Manenti, Francesca Montesanto, Mario Laudazi, Colleen Patricia Ryan, Francesco Giuseppe Garaci, Valeria Fiaschetti, Consuelo Russo, Meucci Rosaria
article en

Abstract

Endometriosis affects approximately 10% of women of reproductive age and is a significant cause of pelvic pain and infertility. It manifests in three patterns: superficial peritoneal lesions, ovarian endometriomas, and deep infiltrating endometriosis (DIE). Our aim is to remind radiologists of the possibility of atypical locations of pelvic and extrapelvic endometriosis and to illustrate their characteristics on magnetic resonance imaging (MRI). The most common site of endometriosis is the ovaries, followed by the pelvic peritoneum. Less common locations include deep subperitoneal tissues, the gastrointestinal tract, the bladder, the thorax, and subcutaneous tissues. We present three rare clinical cases: diaphragmatic endometriosis, inguinal canal endometriosis, and a case of sciatic nerve infiltration. MRI provides important findings that help classify the disease and identify the extent of the lesion, thus facilitating appropriate diagnosis and treatment. Radiologists should be familiar with the MRI findings of DIE in various anatomical sites to provide information that allows for adequate pre-surgical counseling.

Discover MedicineVol. 2(1)
University of Rome Tor Vergata (IT), Policlinico Tor Vergata (IT)
Openalex Percentile: Top 66%
Endometriosis Research and Treatment
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Literature update and MRI case collection of unusual localizations — Flavia Rufi, Guglielmo Manenti, et al. · Discover Medicine (2025) | TGRS Research Map | TGRS