Cross-species Standardised Cortico-Subcortical Tractography

Abstract Despite their importance for brain function, cortico-subcortical white matter tracts are underrepresented in diffusion MRI tractography studies. Their non-invasive mapping is more challenging and less explored compared to other major cortico-cortical bundles. We introduce a set of standardised tractography protocols for delineating tracts between the cortex and various deep subcortical structures, including the caudate, putamen, amygdala, thalamus and hippocampus. To enable comparative studies, our protocols are designed for both human and macaque brains. We demonstrate how tractography reconstructions follow topographical principles obtained from tracers in the macaque and how these translate to humans. We show that the proposed protocols are robust against data quality and preserve aspects of individual variability stemming from family structure in humans. Lastly, we demonstrate the value of these species-matched protocols in mapping homologous grey matter regions in humans and macaques, both in cortex and subcortex.

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Publication Details

Journal
eLife
Published
2025-09-23
DOI
https://doi.org/10.7554/elife.107012.2
Primary Topic
Advanced Neuroimaging Techniques and Applications
Type
article
Field-Weighted Citation Impact
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article

Cross-species Standardised Cortico-Subcortical Tractography

Davide Folloni, Saâd Jbabdi, Shaun Warrington, Katherine Bryant et al.
eLife
Advanced Neuroimaging Techniques and Applications
article

Cross-species Standardised Cortico-Subcortical Tractography

Davide Folloni, Saâd Jbabdi, Shaun Warrington, Katherine Bryant, Stamatios N. Sotiropoulos, Sarah R. Heilbronner, Rogier B. Mars, Stephania Assimopoulos, Ali‐Reza Mohammadi‐Nejad, Wei Tang
article en

Abstract

Abstract Despite their importance for brain function, cortico-subcortical white matter tracts are underrepresented in diffusion MRI tractography studies. Their non-invasive mapping is more challenging and less explored compared to other major cortico-cortical bundles. We introduce a set of standardised tractography protocols for delineating tracts between the cortex and various deep subcortical structures, including the caudate, putamen, amygdala, thalamus and hippocampus. To enable comparative studies, our protocols are designed for both human and macaque brains. We demonstrate how tractography reconstructions follow topographical principles obtained from tracers in the macaque and how these translate to humans. We show that the proposed protocols are robust against data quality and preserve aspects of individual variability stemming from family structure in humans. Lastly, we demonstrate the value of these species-matched protocols in mapping homologous grey matter regions in humans and macaques, both in cortex and subcortex.

eLife
Allen Institute for Brain Science (US), University of Nottingham (GB), Radboud University Nijmegen (NL), Baylor College of Medicine (US), Wellcome Centre for Integrative Neuroimaging (GB), Laboratoire de Psychologie Cognitive (FR), Indiana University Bloomington (US), Queen's Medical Centre (GB), Nottingham Biomedical Research Centre (GB), Icahn School of Medicine at Mount Sinai (US)
Openalex Percentile: Top 61%
Advanced Neuroimaging Techniques and Applications
DOIOpen Access PDFOpenAlex
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