IL1RA<sup>+</sup> Myeloid-derived Suppressor Cells Activate Epithelial-mesenchymal Transition to Facilitate Lymphatic and Hepatic Metastasis in Pancreatic Ductal Carcinoma

IL1RA<sup>+</sup> MDSCs represent a key immunosuppressive and pro-tumorigenic subtype in HM/LNP PDAC, providing a solid theoretical basis for prognostic prediction and the development of immunotherapeutic strategies targeting these cells in HM/LNP PDAC.

Authors

Xinyu Peng
Shengnan Lv
Haijun Li (ORCID: https://orcid.org/0000-0002-2515-3076)
Huan Liu (ORCID: https://orcid.org/0000-0002-2676-6982)
Han Liu (ORCID: https://orcid.org/0000-0002-0014-4675)
Jian Zhang (ORCID: https://orcid.org/0000-0002-7175-1974)
Feng Wei (ORCID: https://orcid.org/0000-0001-8451-4516)

Institutions

Jilin University (CN)
First Hospital of Jilin University (CN)

Publication Details

Journal: Journal of Clinical and Translational Hepatology
Published: 2025-09-24
DOI: https://doi.org/10.14218/jcth.2025.00416
Primary Topic: Pancreatic and Hepatic Oncology Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

IL1RA⁺ Myeloid-derived Suppressor Cells Activate Epithelial-mesenchymal Transition to Facilitate Lymphatic and Hepatic Metastasis in Pancreatic Ductal Carcinoma

Xinyu Peng, Shengnan Lv, Haijun Li, Huan Liu et al.

Sep 24, 2025

Journal of Clinical and Translational Hepatology

Pancreatic and Hepatic Oncology Research

article

IL1RA⁺ Myeloid-derived Suppressor Cells Activate Epithelial-mesenchymal Transition to Facilitate Lymphatic and Hepatic Metastasis in Pancreatic Ductal Carcinoma

Xinyu Peng, Shengnan Lv, Haijun Li, Huan Liu, Han Liu, Jian Zhang, Feng Wei

September 24, 2025article en

Abstract

IL1RA<sup>+</sup> MDSCs represent a key immunosuppressive and pro-tumorigenic subtype in HM/LNP PDAC, providing a solid theoretical basis for prognostic prediction and the development of immunotherapeutic strategies targeting these cells in HM/LNP PDAC.

Journal of Clinical and Translational HepatologyVol. 000(000)

Jilin University (CN), First Hospital of Jilin University (CN)

Openalex Percentile: Top 65%

Pancreatic and Hepatic Oncology Research

DOI Open Access PDF OpenAlex

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IL1RA<sup>+</sup> Myeloid-derived Suppressor Cells Activate Epithelial-mesenchymal Transition to Facilitate Lymphatic and Hepatic Metastasis in Pancreatic Ductal Carcinoma — Xinyu Peng, Shengnan Lv, et al. · Journal of Clinical and Translational Hepatology (2025) | TGRS Research Map | TGRS