High IL-10 mRNA levels in regional lymph nodes of colon cancer patients indicate poor prognosis
Level determinations of IL-10 mRNA in LNs are useful for prediction of outcome for CC patients after curative surgery. Low levels indicate that the patients do not require further treatment, while IL-10 in combination with LGR6 or CXCL17 can be used to identify patients at very high risk of recurrence.
Authors
- Hager Tarek H. Ismail (ORCID: https://orcid.org/0000-0001-9215-7758)
- Sten Hammarström (ORCID: https://orcid.org/0000-0002-4010-4002)
- Faten Zahran (ORCID: https://orcid.org/0000-0001-8237-6711)
- Marie‐Louise Hammarström (ORCID: https://orcid.org/0000-0001-6182-4423)
- Basel Sitohy (ORCID: https://orcid.org/0000-0001-8803-4798)
- G Lindmark (ORCID: https://orcid.org/0000-0002-7125-9533)
- Nabila Zein (ORCID: https://orcid.org/0000-0003-0921-6919)
- Alaa Mohamed (ORCID: https://orcid.org/0000-0001-5193-3319)
Institutions
- Lund University (SE)
- Zagazig University (EG)
- Umeå University (SE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1589533
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kempe Foundation
- Vetenskapsrådet