Macrophage Tim-4 protects against deep vein thrombosis by binding CK2β to suppress inflammatory responses
Our findings demonstrate that macrophage Tim-4, regulated by lncRNF219-3:1/miR-93-5p axis, functions as a critical suppressor of DVT through hijacking and sequestering CK2β to dampen NF-κB mediated inflammation. The study unveils novel immunomodulatory mechanisms in DVT pathogenesis and highlights Tim-4 and its regulatory network as potential therapeutic targets for DVT in clinic.
Authors
- Fuxiang Bai (ORCID: https://orcid.org/0000-0001-7752-0803)
- Xu Chen (ORCID: https://orcid.org/0000-0002-2158-8320)
- Zhijun Yu (ORCID: https://orcid.org/0000-0003-4588-8800)
- Ke Xu (ORCID: https://orcid.org/0000-0002-5465-3301)
- Qiang Guo (ORCID: https://orcid.org/0000-0001-5403-0692)
- Wen Liu (ORCID: https://orcid.org/0000-0003-3434-4162)
- Junjie Chen (ORCID: https://orcid.org/0000-0002-8984-1986)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-5552-2354)
- Xia Li (ORCID: https://orcid.org/0000-0002-9794-2648)
- Chu Chu (ORCID: https://orcid.org/0000-0002-8151-1157)
- Cui Liu (ORCID: https://orcid.org/0000-0003-3629-1252)
- Bin Wang (ORCID: https://orcid.org/0000-0001-9097-4578)
- Songbo Zhao
- Zhen Zhang (ORCID: https://orcid.org/0000-0002-3764-792X)
- Weiwei Zheng (ORCID: https://orcid.org/0000-0003-0806-2997)
- Baohui Zhang (ORCID: https://orcid.org/0009-0009-3543-8516)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1634230
- Citations
- 1
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.80