Widespread and progressive brain atrophy is a common feature in patients with mitochondrial disease
Cerebral atrophy is a common and often progressive feature of mitochondrial disease, even in patients without clinical brain symptoms. Atrophy predominantly affects posterior brain regions, and its progression is particularly evident in patients with SLEs. These findings underline the neurodegenerative nature of mitochondrial disease and highlight the need to develop neuroprotective therapies.
Authors
- Jussi Hirvonen (ORCID: https://orcid.org/0000-0002-0368-3746)
- Mika Henrik Martikainen (ORCID: https://orcid.org/0000-0002-7604-8081)
- Nora Mickelsson
Institutions
- Tampere University of Applied Sciences (FI)
- University of Turku (FI)
- Oulu University Hospital (FI)
- Turku University Hospital (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Oulu University of Applied Sciences (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1007/s00415-025-13354-z
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Turun Yliopisto