Morphometric MRI findings in patients with suspected autoimmune psychosis spectrum syndromes and association with EEG slowing, CSF changes, and psychometric/neuropsychological findings
Autoantibody-associated suspected AP spectrum syndromes seem to be associated with slight global grey matter volume reductions and secondary increased CSF volumes. Associations between hippocampal volume increases and inflammatory CSF markers could, in contrast, reflect edematous swelling within the limbic system. Further multimodal imaging studies of more homogeneous AP groups might be promising to detect morphometric correlates.
Authors
- Bernd Feige (ORCID: https://orcid.org/0000-0002-9436-1258)
- Katharina Domschke (ORCID: https://orcid.org/0000-0002-2550-9132)
- Nils Venhoff (ORCID: https://orcid.org/0000-0001-7729-2759)
- Katharina von Zedtwitz
- Thomas Lange (ORCID: https://orcid.org/0000-0002-7467-8143)
- Ludger Tebartz van Elst (ORCID: https://orcid.org/0000-0002-2274-5447)
- Harald Prüß (ORCID: https://orcid.org/0000-0002-8283-7976)
- Simon Maier (ORCID: https://orcid.org/0000-0002-4285-8174)
- Isabelle Matteit
- Kimon Runge (ORCID: https://orcid.org/0000-0002-0263-4360)
- Marco Reisert (ORCID: https://orcid.org/0000-0003-2742-1940)
- Andrea Schlump (ORCID: https://orcid.org/0009-0000-8677-9454)
- Dominique Endres (ORCID: https://orcid.org/0000-0001-7322-1195)
- Kathrin Nickel (ORCID: https://orcid.org/0000-0001-9863-317X)
- Alexander Rau (ORCID: https://orcid.org/0000-0001-5881-6043)
Institutions
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- German Center for Neurodegenerative Diseases (DE)
- German Centre for Cardiovascular Research (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1648946
- Citations
- 2
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78