Alisol A 24-acetate protects against NASH-associated fibrosis via suppression of Kupffer cell-derived SPHK1/S1P axis
AA exerts potent anti-steatotic, anti-inflammatory, and antifibrotic effects in experimental NASH, primarily by targeting the SPHK1/S1P signaling axis in Kupffer cells. This study is the first to identify AA as a direct modulator of KC-derived SPHK1 signaling, offering a novel strategy to disrupt KC-HSC crosstalk and mitigate liver fibrosis in NASH.
Authors
- Shuming Pan (ORCID: https://orcid.org/0000-0002-6922-5545)
- Liang Shi (ORCID: https://orcid.org/0000-0002-4325-2879)
- Yuanye Jiang
- Cheng Hu (ORCID: https://orcid.org/0000-0003-4314-2386)
- Jiaqi Zhang (ORCID: https://orcid.org/0000-0002-4606-1250)
- Jiayang Wang (ORCID: https://orcid.org/0000-0002-5551-8611)
- Pei-Qi Sun
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.phymed.2025.157271
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00