Taraxasterol alleviates osteoporosis by targeting PI3K/AKT/PPARγ signaling axis to suppress necroptosis and reverse osteogenic-adipogenic differentiation imbalance in BMSCs
Our study reveals for the first time that TAX restores osteogenic-adipogenic equilibrium in OP-BMSCs and promotes bone regeneration through PI3K/AKT/PPARγ activation and mitochondrial protection-mediated suppression of necroptosis. These results position TAX as a promising therapeutic candidate for osteoporosis.
Authors
- Chenying Zeng (ORCID: https://orcid.org/0000-0002-8743-4447)
- Zhichao Xiao
- Qingqiang Tu
- Linjian Chen
- Yanfeng Wu (ORCID: https://orcid.org/0000-0003-3929-9823)
- Weihao Zhang (ORCID: https://orcid.org/0000-0002-9301-8538)
- Jiong Lin (ORCID: https://orcid.org/0000-0002-7027-1178)
- Zhongyu Xie
- Ziyang Zhang (ORCID: https://orcid.org/0009-0000-4757-7534)
- Wenhui Yu (ORCID: https://orcid.org/0000-0002-0684-5237)
- Qibo Li (ORCID: https://orcid.org/0009-0006-7925-1225)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Affiliated Hospital of Jinan University (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.phymed.2025.157277
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81