Ailanthone targets mitophagy-loaded SIRT4 to facilitate the deacetylation of HIF1α, triggering oxidative stress for gastric carcinoma treatment
Our results revealed that AIL targeted mitophagy-loaded SIRT4 to regulate redox homeostasis, inducing mitochondrial dysfunction-mediated cell apoptosis and inhibiting gastric cancer growth. These findings provide strong evidence for the potential clinical use of AIL in gastric cancer treatment.
Authors
- Shaotong Li
- Ting Ma (ORCID: https://orcid.org/0000-0002-1597-0582)
- Xiaolei Lian
- Huijun Zhao (ORCID: https://orcid.org/0000-0002-5365-1419)
- Mengge Dai
- Xianzhi Liu (ORCID: https://orcid.org/0000-0002-4684-0721)
- Xiangyu Xu (ORCID: https://orcid.org/0000-0002-1628-906X)
- Yajun Lian (ORCID: https://orcid.org/0000-0001-8971-9545)
Institutions
- Ministry of Education (NZ)
- Zhengzhou University (CN)
- Zhengzhou University of Science and Technology (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.phymed.2025.157283
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.22