Optimal stimulation of the thalamic centromedian nucleus in children with Lennox-Gastaut syndrome: patient series
CM-DBS is a promising treatment for pediatric, medically refractory LGS when resective approaches are unsuitable. Benefits were sustained over years. Lead localization and direction of stimulation appear important to optimize clinical benefit. These findings support the feasibility and safety of pediatric CM-DBS and highlight the need for prospective trials incorporating EEG-based outcomes and patient-centered measures including comorbidities and quality of life. Early, network-targeted neuromodulation may improve long-term outcomes. https://thejns.org/doi/10.3171/CASE25478.
Authors
- Aaron E. L. Warren (ORCID: https://orcid.org/0000-0001-6534-2800)
- Audrey Xu (ORCID: https://orcid.org/0000-0002-8717-6185)
- T Johnstone
- Gerald A. Grant (ORCID: https://orcid.org/0000-0002-2651-4603)
- Maria Isabel Barros Guinle (ORCID: https://orcid.org/0000-0001-5687-3941)
- Ann Hyslop (ORCID: https://orcid.org/0000-0002-2971-7131)
- Jonathon J. Parker (ORCID: https://orcid.org/0000-0002-0531-8400)
- Vivek Buch (ORCID: https://orcid.org/0000-0003-1151-6128)
- Juliet K. Knowles (ORCID: https://orcid.org/0000-0002-9214-2991)
- Brenda E. Porter (ORCID: https://orcid.org/0000-0001-6346-7327)
- Prathyusha Teeyagura (ORCID: https://orcid.org/0009-0001-6255-5648)
- Hyunmi Kim (ORCID: https://orcid.org/0000-0003-2459-7836)
- Rayann M. Solidum
Institutions
- Duke University (US)
- WinnMed (US)
- Massachusetts General Hospital (US)
- Mayo Clinic in Florida (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of Neurosurgery Case Lessons
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3171/case25478
- Citations
- 2
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94