Integrated multi-omics profiling reveals shared mechanistic pathways in asthma-allergic rhinitis comorbidity: A hybrid machine learning framework leveraging Mendelian randomization for precision diagnostics
This integrative analysis establishes RPS4Y1 as a central regulator of allergic inflammation dimorphism and delivers a validated multi-omics classifier for precision diagnostics. The findings bridge molecular sex differences, metabolic-immune crosstalk, and clinical heterogeneity, advancing phenotype-specific therapeutic strategies.
Authors
- Chunlin Li (ORCID: https://orcid.org/0009-0007-5263-6579)
- Wenxin Wang (ORCID: https://orcid.org/0000-0002-4370-7028)
- Hehe Wang (ORCID: https://orcid.org/0000-0002-5484-1548)
- Ziyi Yuan
- Yaowen Wang (ORCID: https://orcid.org/0000-0002-6877-8017)
- Jiagang Tu (ORCID: https://orcid.org/0000-0001-5447-4699)
- Junge Zhang (ORCID: https://orcid.org/0000-0002-9970-394X)
Institutions
- Ningbo University Affiliated Hospital (CN)
- Ningbo First Hospital (CN)
Publication Details
- Journal
- World Allergy Organization Journal
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.waojou.2025.101120
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16