Characterization of a major house dust mite allergen Der p 22 among Malaysian adult population
Der p 22 is a clinically relevant HDM allergen in the Malaysian adult population. It harbours both unique and shared IgE epitopes with Der p 2, highlighting its value for inclusion in molecular diagnostic panels to improve allergen sensitization profiling. Alanine mutation to 6 amino acid residues of Der p 22 significantly reduced IgE binding, suggesting its potential as a candidate hypoallergen molecule in allergen-specific immunotherapy.
Authors
- Smyrna Moti Rawanan Shah (ORCID: https://orcid.org/0000-0002-9150-2094)
- Kavita Reginald (ORCID: https://orcid.org/0000-0003-1530-5934)
- Fook Tim Chew (ORCID: https://orcid.org/0000-0003-1337-5146)
- Yang Yie Sio (ORCID: https://orcid.org/0000-0002-3549-1706)
- Alexis P Lee (ORCID: https://orcid.org/0009-0000-0635-5206)
Institutions
- National University of Singapore (SG)
- Sunway University (MY)
Publication Details
- Journal
- World Allergy Organization Journal
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.waojou.2025.101117
- Citations
- 1
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 1.62