Antisense phosphorodiamidate morpholino oligomers retain activity in Burkholderia cepacia complex biofilm
The Bcc biofilm setting is not a deterrent against PPMO delivery or antimicrobial activity. This is supported by the colocalization of AcpP PPMOs with cells, membrane destruction, loss of cell viability, and biomass reduction. Collectively, these data provide evidence that AcpP PPMOs are a promising therapeutic strategy in the treatment of Bcc infections.
Authors
- David E. Greenberg (ORCID: https://orcid.org/0000-0002-5101-3106)
- Christine Pybus (ORCID: https://orcid.org/0000-0002-4895-6525)
- Antonio R. Mendez
Institutions
- The University of Texas at Dallas (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fmicb.2025.1660799
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00