Association of salivary lactoferrin, Porphyromoras gingivalis and stress hormone levels in patients with periodontitis: a pilot study
Our findings suggest that elevated lactoferrin, DHEA and cortisol levels reflect both immune-inflammatory and stress-mediated pathways in periodontitis, and its association with the abundance of <i>P. gingivalis</i> in saliva and subgingival area. This study supports immune and hormonal dysregulation in periodontal patients, with potential implications in systemic diseases, including such as AD, where lactoferrin levels are seriously altered.
Authors
- Cristina Municio (ORCID: https://orcid.org/0000-0002-8552-8183)
- Elena Buetas (ORCID: https://orcid.org/0000-0003-3610-2140)
- Laura Carrero (ORCID: https://orcid.org/0000-0001-8490-6253)
- Eva Carro (ORCID: https://orcid.org/0000-0002-6504-4579)
- Álex Mira (ORCID: https://orcid.org/0000-0002-9127-3877)
- Sandra García‐Esteban
- Desireé Antequera
- Deborah Romualdi
Institutions
- Universidad Nacional de Educación a Distancia (ES)
- Instituto de Salud Carlos III (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
- Unidad Funcional de Investigación de Enfermedades Crónicas (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1681095
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- European Commission
- Ministerio de Ciencia e Innovación
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Instituto de Salud Carlos III