Vitamin D-inducible antimicrobial peptide LL-37 binds SARS-CoV-2 Spike and accessory proteins ORF7a and ORF8
LL-37 disrupts key viral-host interactions by binding to Spike, ORF7a, and ORF8, thereby reducing SARS-CoV-2 infectivity. These findings highlight LL-37's potential as a therapeutic agent in COVID-19 and provide mechanistic insight into its antiviral actions.
Authors
- Ines Neundorf (ORCID: https://orcid.org/0000-0001-6450-3991)
- Gabriele Hermes
- Dzemal Elezagic (ORCID: https://orcid.org/0000-0003-1041-8470)
- Gerhard Sengle (ORCID: https://orcid.org/0000-0003-3932-1242)
- Denise Meinberger (ORCID: https://orcid.org/0000-0002-7786-6000)
- Marco Drexelius (ORCID: https://orcid.org/0000-0002-5813-2116)
- Steffen Lütke (ORCID: https://orcid.org/0000-0001-6924-7990)
- Jan Gebauer (ORCID: https://orcid.org/0000-0002-3167-4695)
- Matthias Mörgelin (ORCID: https://orcid.org/0000-0002-6212-6990)
- Annika Roth (ORCID: https://orcid.org/0000-0002-3376-0968)
- Mats Paulsson (ORCID: https://orcid.org/0000-0002-6846-857X)
- Andreas R. Klatt (ORCID: https://orcid.org/0000-0002-8517-7512)
- Manuel Koch (ORCID: https://orcid.org/0000-0002-2962-7814)
- Thomas Streichert (ORCID: https://orcid.org/0000-0002-6588-720X)
Institutions
- TH Köln - University of Applied Sciences (DE)
- University of Cologne (DE)
- Lund University (SE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Ideon Innovation (Sweden) (SE)
- University Hospital Cologne (DE)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fcimb.2025.1671738
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40