Elevated <scp>N6</scp> ‐Methyladenosine ( <scp>m6A</scp> )‐ <scp>RNA</scp> ‐Methylation During Oral Carcinogenesis
Our study revealed that the level of m6A-RNA methylation in the epithelial tissues of OED and OSCC was higher than that in oral normal epithelium, suggesting that the methylation modification might be involved in the occurrence of OED and its progression to OSCC. Furthermore, hypermethylation and upregulated expression of C4B, DNAH9, and NCALD were associated with a favorable prognosis in these diseases.
Authors
- Yanting Chi
- Jing Yan (ORCID: https://orcid.org/0009-0002-0857-8248)
- Binbin Li (ORCID: https://orcid.org/0000-0003-0521-2945)
- Xinpei Wang (ORCID: https://orcid.org/0000-0001-5589-0096)
- Xinning Zhang (ORCID: https://orcid.org/0000-0002-3617-3582)
- Zhiming Qin
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- National Clinical Research (US)
Publication Details
- Journal
- Journal of Oral Pathology and Medicine
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1111/jop.70066
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00