Quantitative analysis of serum metabolites in a rat model of Alzheimer’s disease
The most significant differences between OXYS and Wistar blood metabolomes were found for 20-day-old animals, which corresponds to the preclinical period of AD development in humans. Metabolomic changes observed in the brain and blood are different and often opposite in sign. Blood serum is potentially promising fluid for AD diagnosis.
Authors
- Yuri P. Tsentalovich (ORCID: https://orcid.org/0000-0002-1380-3000)
- Darya V. Telegina (ORCID: https://orcid.org/0000-0001-8096-0519)
- Н. Г. Колосова (ORCID: https://orcid.org/0000-0003-2398-8544)
- Alexander Smolentsev (ORCID: https://orcid.org/0000-0002-1930-5264)
- Olga A. Snytnikova (ORCID: https://orcid.org/0000-0001-9089-1924)
Institutions
- Novosibirsk State University (RU)
- Institute of Cytology and Genetics (RU)
- International Tomography Center (RU)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fnagi.2025.1648561
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Siberian Branch, Russian Academy of Sciences
- Russian Science Foundation