Dual fungal endocarditis in a pediatric dialysis patient: First case of Aspergillus flavus and Candida parapsilosis co-infection

We report the first pediatric case of dual fungal infective endocarditis (IE) caused by <i>Aspergillus flavus</i> and <i>Candida parapsilosis</i> in a dialysis-dependent child from a conflict-affected region. Diagnosis was supported by galactomannan monitoring, histopathology, and molecular sequencing. Management required early surgery and prolonged dual antifungal therapy. Despite the rarity and severity of such coinfections, the patient survived. This case highlights the importance of early recognition, multidisciplinary care, and aggressive treatment in pediatric fungal IE.

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Publication Details

Journal
Medical Mycology Case Reports
Published
2025-09-23
DOI
https://doi.org/10.1016/j.mmcr.2025.100735
Primary Topic
Antifungal resistance and susceptibility
Type
article
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article

Dual fungal endocarditis in a pediatric dialysis patient: First case of Aspergillus flavus and Candida parapsilosis co-infection

Fatima A. Al Dhaheri, Akela Ghazawi, Hari Pankaj Vanam, Tasneem Basha et al.
Medical Mycology Case Reports
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article

Dual fungal endocarditis in a pediatric dialysis patient: First case of Aspergillus flavus and Candida parapsilosis co-infection

Fatima A. Al Dhaheri, Akela Ghazawi, Hari Pankaj Vanam, Tasneem Basha, Abdullah Ahmed Al‐Ghamdi, Amina Bakro
article en

Abstract

We report the first pediatric case of dual fungal infective endocarditis (IE) caused by <i>Aspergillus flavus</i> and <i>Candida parapsilosis</i> in a dialysis-dependent child from a conflict-affected region. Diagnosis was supported by galactomannan monitoring, histopathology, and molecular sequencing. Management required early surgery and prolonged dual antifungal therapy. Despite the rarity and severity of such coinfections, the patient survived. This case highlights the importance of early recognition, multidisciplinary care, and aggressive treatment in pediatric fungal IE.

Medical Mycology Case ReportsVol. 50
Al Ain University (AE), United Arab Emirates University (AE), Shaikh Khalifa Medical City (AE), Al Ain Hospital (AE), Abu Dhabi Health Services (AE)
Openalex Percentile: Top 69%
Antifungal resistance and susceptibility
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