Peripheral monocytes from Crohn’s disease patients retain functional responsiveness to GM-CSF during active disease
Peripheral monocytes from aCD patients retain functional responsiveness to GM-CSF activation, displaying preserved migratory, adhesive, metabolic, and cytokine responses. Differences in cytokine production by aCD monocytes may reflect disease-specific regulation, but do not appear to limit their suitability as cellular therapeutics.
Authors
- Paul P. Winkel (ORCID: https://orcid.org/0000-0003-3760-6287)
- Rosaely Casalegno‐Garduño (ORCID: https://orcid.org/0000-0002-2206-6508)
- Ida Maria Wrobel
- Grażyna Domańska (ORCID: https://orcid.org/0000-0001-9710-6386)
- Johannes Reiner
- Elisa Wirthgen (ORCID: https://orcid.org/0000-0002-8696-1675)
- Jan Däbritz (ORCID: https://orcid.org/0000-0003-4219-5283)
- Wendy Bergmann‐Ewert (ORCID: https://orcid.org/0000-0001-7221-3900)
- A Huth
- Dana Kleimeier
Institutions
- University of Potsdam (DE)
- Universitätsmedizin Greifswald (DE)
- Klinikum Oldenburg (DE)
- Zittau/Görlitz University of Applied Sciences (DE)
- University of Rostock (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1663713
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00