IL-6 trans-signaling in cystic fibrosis bronchial cells potentiates TNF-α-driven ICAM-1 expression
Our data unveiled that ICAM-1, which promotes neutrophil adhesion, is upregulated by the combination of TNF-α and IL-6 signaling in CF bronchial cells. Interestingly, soluble IL-6R (sIL-6Rα) protects IL-6 from degradation by bacterial proteases. Therefore, we suggest that strategies which target IL-6 trans-signaling may alleviate ICAM-1 mediated neutrophil adhesion and reduce subsequent lung damage in PEx.
Authors
- Dao M. Nguyen (ORCID: https://orcid.org/0000-0003-4012-5441)
- Lyvia Fourcade
- Julie Bérubé
- Simon Rousseau (ORCID: https://orcid.org/0000-0002-8773-575X)
- John Q. Lin
- Lucie Roussel (ORCID: https://orcid.org/0000-0003-4697-2270)
- Matthew Marabella
Institutions
- McGill University Health Centre (CA)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fcell.2025.1566482
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16