Single-cell multi-omics and nursing follow-up prognostic modeling reveal SLFN4-mediated neutrophil dysregulation in traumatic brain injury
SLFN4<sup>+</sup> neutrophils represent a key inflammatory effector population contributing to early immune dysregulation after TBI. Beyond mechanistic insights, SLFN4 serves as a promising serum biomarker to enhance clinical decision-making and nursing risk stratification. These findings support the integration of immunological biomarkers into precision nursing frameworks to guide early interventions and improve neurorehabilitation outcomes.
Authors
- Yuhui Yuan (ORCID: https://orcid.org/0000-0002-7109-6703)
- Fangfang Ding
- Fu Zhao (ORCID: https://orcid.org/0000-0002-5286-5650)
- Zhuang Li (ORCID: https://orcid.org/0009-0006-8346-5488)
- Jing Ke (ORCID: https://orcid.org/0000-0001-7459-257X)
- Xiumei Zhang (ORCID: https://orcid.org/0000-0001-5200-989X)
- Yang Wang (ORCID: https://orcid.org/0000-0002-2626-478X)
- Hong Yang (ORCID: https://orcid.org/0000-0003-4670-9608)
- Wencan Xu (ORCID: https://orcid.org/0000-0002-9270-6937)
- Duan Wei (ORCID: https://orcid.org/0000-0003-0037-5796)
- Lina Wang (ORCID: https://orcid.org/0000-0003-3665-5706)
- Tingting Shi (ORCID: https://orcid.org/0000-0003-3599-4116)
- Hong-Yan Cai (ORCID: https://orcid.org/0000-0003-3336-8808)
- Hongling Jia
- Wenping Tang (ORCID: https://orcid.org/0000-0002-8771-3120)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Jinan University (CN)
- Anhui Medical University (CN)
- Shanghai Ninth People's Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- National Science Centre (PL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1669800
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00