Vespa orientalis pupae peptide hydrolysates modulate NF-κB signaling in LTA-induced pneumonia from clinical Enterococcus faecalis isolates: implications for gut microbiota
These results indicate that PPH mitigates LTA-induced pneumonia by reinforcing the intestinal barrier, modulating inflammatory pathways, including suppression of NF-κB, and restoring microbial balance. PPH represents a promising new approach for managing pneumonia as a chronic inflammatory disease.
Authors
- Yamina Alioui
- Nabeel Ahmed Farooqui
- Sharafat Ali (ORCID: https://orcid.org/0000-0001-7893-4055)
- Yi Xin (ORCID: https://orcid.org/0000-0002-6988-5121)
- Muhsin Ali
- Mujeeb Ur Rahman (ORCID: https://orcid.org/0000-0002-8748-8066)
- Jiayi Wang (ORCID: https://orcid.org/0000-0002-1313-138X)
- Liang Wang (ORCID: https://orcid.org/0000-0001-5339-7484)
- Ting Deng (ORCID: https://orcid.org/0000-0001-5477-7972)
- Renzhen Ma
- A. H. Atta
- Muhammad Ilyas (ORCID: https://orcid.org/0000-0002-7437-0819)
- Hidayat Ullah (ORCID: https://orcid.org/0000-0003-3500-3861)
- Mohammed Abusidu
Institutions
- Guangdong Medical College (CN)
- Guangdong Pharmaceutical University (CN)
- Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fnut.2025.1651499
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 0.00