Effects of sex but not race and geographic origin on vaccine-induced HIV-specific antibody responses
Female sex was associated with higher vaccine-induced IgG Envelope-specific binding antibody titers and recognition of V2 region of HIV Envelope in HVTN 204 volunteers. No such associations were detected for race or geographic location. Understanding biological factors driving these sex-based differences may improve the design of a new generation of HIV vaccine candidates.
Authors
- Mkunde Chachage (ORCID: https://orcid.org/0000-0003-2196-1073)
- Lucas Maganga (ORCID: https://orcid.org/0000-0001-7519-0628)
- Wilbert Mbuya (ORCID: https://orcid.org/0000-0002-0216-4717)
- Zoe Moodie (ORCID: https://orcid.org/0000-0001-8701-2001)
- Gavin Churchyard (ORCID: https://orcid.org/0000-0002-4269-3699)
- Christof Geldmacher (ORCID: https://orcid.org/0000-0001-6777-7621)
- Linda‐Gail Bekker (ORCID: https://orcid.org/0000-0002-0755-4386)
- Michael C. Keefer (ORCID: https://orcid.org/0000-0001-9048-3621)
- Augusta Horvath
- Kathrin Held (ORCID: https://orcid.org/0000-0001-7057-6935)
- Ann Duerr (ORCID: https://orcid.org/0000-0002-3399-2208)
- Christiane Moog (ORCID: https://orcid.org/0000-0002-0916-156X)
- Edna Viegas (ORCID: https://orcid.org/0000-0003-4691-9920)
- Michael Hoelscher (ORCID: https://orcid.org/0000-0003-0989-5528)
Institutions
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Infectious Disease Research Institute (US)
- Desmond Tutu HIV Foundation (ZA)
- Inserm (FR)
- University of the Witwatersrand (ZA)
- Vanderbilt University (US)
- Helmholtz Zentrum München (DE)
- LMU Klinikum (DE)
- Mbeya University of Science and Technology (TZ)
- Fred Hutch Cancer Center (US)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- German Center for Infection Research (DE)
- Institut de Recherche Vaccinale (FR)
- Aurum Institute (ZA)
- Instituto Nacional de Saúde (MZ)
- National Institute for Medical Research (TZ)
- University of Rochester (US)
- Université de Strasbourg (FR)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1601865
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vanderbilt University
- University of Rochester
- Inyuvesi Yakwazulu-Natali
- University of Cape Town
- Weill Cornell Medical College