MyD88 orchestrates fatty acid metabolism in tumor-associated macrophages and non-alcoholic fatty liver disease-related hepatocarcinogenesis
MyD88 in macrophages has a promotional role in NAFLD-associated HCC. MyD88 promotes macrophage M2 polarization, which enhances the progression of NAFLD to HCC by activating the SREBP1/STAT6 pathway. MyD88 in macrophages may be a potential therapeutic and/or preventive target for NAFLD-associated HCC.
Authors
- Zhenzhong Deng (ORCID: https://orcid.org/0000-0002-6263-7328)
- Jianchun Gu
- Zuyin Li
- Jinhua Zhang (ORCID: https://orcid.org/0000-0001-8957-8893)
- Chien‐Jen Chen (ORCID: https://orcid.org/0000-0002-5799-6705)
- Xuanxuan Yan
- Fanxin Zeng (ORCID: https://orcid.org/0000-0002-7337-4463)
- Li Zhao (ORCID: https://orcid.org/0000-0002-9873-8745)
Institutions
- Peking University (CN)
- Beijing Jiaotong University (CN)
- XinHua Hospital (CN)
- Peking University People's Hospital (CN)
- Dazhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1589255
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00