Results and indications changes by prenatal diagnosis of 3,458 pregnant women: a 10-year retrospective study
In recent 10 years, prenatal diagnosis indications in Heilongjiang Province have shifted to a "NIPT high-risk + abnormal ultrasound" pattern. Combined karyotype and CNV-seq testing achieves a 20.36% anomaly detection rate. NIPT enables non-invasive screening for fetal chromosome aneuploidy, while CNV-seq - a key technology for accurate prenatal diagnosis - helps reduce birth defects.
Authors
- Ruijing Wang
- Yanhui Zhang (ORCID: https://orcid.org/0000-0002-8865-8338)
- Meimei Liu (ORCID: https://orcid.org/0000-0003-1440-4754)
- Xianghan Zhang (ORCID: https://orcid.org/0000-0002-4373-0850)
- Qiao Li (ORCID: https://orcid.org/0000-0001-8059-2293)
- Chao Wang (ORCID: https://orcid.org/0000-0003-2737-4048)
- Yu Liu
- Xin Huang (ORCID: https://orcid.org/0000-0001-9924-1055)
- Haomiao Zhang
Institutions
- Capital University (US)
- Harbin Medical University (CN)
- Capital Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1080/07853890.2025.2563753
- Citations
- 1
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 3.49