<scp>CRISPR</scp> Screens Identify <i>PIK3C2A</i> as a Novel Mediator of <scp>EGFR</scp> Inhibitor Resistance in Head and Neck Squamous Cell Carcinoma
Our data suggests that PIK3C2A is a novel mediator of EGFR inhibitor resistance in HNSCC. Future studies are required to determine the mechanisms by which PIK3C2A drives EGFR inhibitor resistance.
Authors
- Jingyi Zhai (ORCID: https://orcid.org/0000-0003-0475-8786)
- Andrew C. Birkeland (ORCID: https://orcid.org/0000-0003-2500-2857)
- Jiayu Wang (ORCID: https://orcid.org/0000-0003-1967-389X)
- Paul Swiecicki (ORCID: https://orcid.org/0000-0003-2286-3555)
- Megan Ludwig (ORCID: https://orcid.org/0000-0003-3133-3679)
- Matthew E. Spector (ORCID: https://orcid.org/0000-0001-7646-6075)
- Nicole L. Michmerhuizen (ORCID: https://orcid.org/0000-0002-9960-5119)
- Aditi Kulkarni (ORCID: https://orcid.org/0000-0002-4886-6095)
- Elizabeth Gensterblum‐Miller (ORCID: https://orcid.org/0000-0002-8714-1257)
- Marisa R. Buchakjian (ORCID: https://orcid.org/0000-0001-8261-1566)
- J. Chad Brenner (ORCID: https://orcid.org/0000-0003-3238-1111)
- Steven Bennett Chinn (ORCID: https://orcid.org/0000-0003-4282-0640)
- Molly E. Heft Neal (ORCID: https://orcid.org/0000-0002-8813-5537)
- Hui Jiang (ORCID: https://orcid.org/0000-0003-2718-9811)
Institutions
- University of Michigan (US)
- Michigan Medicine (US)
- University of Pittsburgh Medical Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Head & Neck
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1002/hed.70048
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Institutes of Health