β-tricalcium phosphate/calcium sulfate loaded with contezolid acefosamil (MRX-4) for antimicrobial potency, prevention and killing efficacy of MRSA biofilm
MRX-4 combined with gentamicin, delivered via CS and β-TCP/CS carriers, exhibits superior and sustained local antimicrobial efficacy compared to vancomycin, particularly in eradicating MRSA biofilms.
Authors
- Nan Jiang (ORCID: https://orcid.org/0000-0003-2416-1653)
- Haoyang Wan
- Guanqiao Liu (ORCID: https://orcid.org/0000-0003-4119-3796)
- Mou-Zhang Huang
- Peng Chen (ORCID: https://orcid.org/0000-0002-0667-5311)
- Bin Yu (ORCID: https://orcid.org/0000-0002-7549-9753)
- Qing‐rong Lin
- Zixian Liu (ORCID: https://orcid.org/0000-0002-8447-5593)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-6036-2685)
Institutions
- Ganzhou People's Hospital (CN)
- Nanfang Hospital (CN)
- Jiangmen Wuyi Traditional Chinese Medicine Hospital (CN)
- Lanzhou University Second Hospital (CN)
- Hainan General Hospital (CN)
- Southern Medical University (CN)
- Lanzhou University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fphar.2025.1657099
- Primary Topic
- Antimicrobial agents and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00