FKBP9 enhances IGF2BP1-mediated m6A recognition to promote hepatocellular carcinoma progression
This study highlights the critical role of FKBP9 in hepatocellular carcinoma progression by regulating IGF2BP1-mediated m6A RNA recognition, thereby enhancing the stability of key oncogenic transcripts such as <i>MYC</i> and <i>PDGFB</i>. These findings provide new insights into the molecular mechanisms driving hepatocellular carcinoma and identify potential therapeutic opportunities for patients with poor prognosis linked to high FKBP9 expression. The FKBP9-IGF2BP1 axis may serve as both a biomarker and a therapeutic target to guide the development of new treatment strategies. Further studies are warranted to validate these results in larger patient cohorts and to assess the clinical feasibility of targeting this pathway.
Authors
- Yanuo Chen
- Zhengqing Lei (ORCID: https://orcid.org/0000-0001-6009-8984)
- Fangliang Xie
- Anfeng Si
- Xuewu Tang
- Tongfeng Liu
- Yongbo Pan (ORCID: https://orcid.org/0000-0002-3850-7304)
- Weihu Ma
- Zhangjun Cheng (ORCID: https://orcid.org/0000-0001-6500-7535)
- Jiang Zhu (ORCID: https://orcid.org/0000-0003-4194-2355)
- Shan Gao (ORCID: https://orcid.org/0009-0002-1705-8033)
- Facai Yang (ORCID: https://orcid.org/0000-0002-8402-5488)
- Yigang He (ORCID: https://orcid.org/0000-0002-9731-0501)
- Yinmin Gu (ORCID: https://orcid.org/0000-0001-9825-5447)
- Cheng Chi (ORCID: https://orcid.org/0000-0001-9638-064X)
- Hongping Xia (ORCID: https://orcid.org/0009-0009-8902-0764)
- Qiushi Yu
Institutions
- Guiyang Medical University (CN)
- Xuzhou Medical College (CN)
- Guizhou University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Zhongda Hospital Southeast University (CN)
- The First People’s Hospital of Lianyungang (CN)
- Southeast University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101584
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Southeast University
- National Science and Technology Major Project