Alterations in functional connectivity analyzed using MREG in patients with suspected autoimmune psychosis spectrum syndromes
Patients with suspected AP spectrum syndromes exhibit altered insular functional connectivity associated with the severity of depressive symptoms. Broader changes identified via hypothesis-generating analyses highlighted major hubs in the cerebellum, frontal brain, and thalamus. These findings suggest that functional MRI may serve as an additional tool for detecting patients with AP/APS. Future studies in more homogeneous autoimmune-mediated patient groups may help delineate specific connectivity signatures in functional networks.
Authors
- Bernd Feige (ORCID: https://orcid.org/0000-0002-9436-1258)
- Katharina Domschke (ORCID: https://orcid.org/0000-0002-2550-9132)
- Katharina von Zedtwitz
- Thomas Lange (ORCID: https://orcid.org/0000-0002-7467-8143)
- Ludger Tebartz van Elst (ORCID: https://orcid.org/0000-0002-2274-5447)
- Harald Prüß (ORCID: https://orcid.org/0000-0002-8283-7976)
- Jessica A. Weiser
- Simon Maier (ORCID: https://orcid.org/0000-0002-4285-8174)
- Isabelle Matteit
- Kimon Runge (ORCID: https://orcid.org/0000-0002-0263-4360)
- Marco Reisert (ORCID: https://orcid.org/0000-0003-2742-1940)
- Andrea Schlump (ORCID: https://orcid.org/0009-0000-8677-9454)
- Dominique Endres (ORCID: https://orcid.org/0000-0001-7322-1195)
- Kathrin Nickel (ORCID: https://orcid.org/0000-0001-9863-317X)
- Alexander Rau (ORCID: https://orcid.org/0000-0001-5881-6043)
Institutions
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- German Center for Neurodegenerative Diseases (DE)
- German Centre for Cardiovascular Research (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.bbih.2025.101111
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00