Administration of a novel reprogramming formula improves cardiac function and decreases cardiac fibrosis in a myocardial infarction model
Adenoviral mediated administration of VEGF+TID/HM to the rat heart induced improvements in cardiac function and decreased fibrosis after myocardial infarction equivalent to that observed with VEGF+GMT administration. Given the efficacy of VEGF+TID/HM versus VEGF+GMT in cardio-differentiating human cells, these findings suggest the use of VEGF+TID/HM as a potential human myocardial regeneration strategy.
Authors
- Jianchang Yang (ORCID: https://orcid.org/0000-0003-4222-2376)
- Todd K. Rosengart
- Megumi Mathison (ORCID: https://orcid.org/0000-0003-4117-4579)
- Aliya A. Lackan
- Mohamed O. Mohamed (ORCID: https://orcid.org/0000-0002-9678-5222)
- Saliha Pathan (ORCID: https://orcid.org/0000-0002-6271-2359)
Institutions
- Baylor College of Medicine (US)
Publication Details
- Journal
- JTCVS Open
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.xjon.2025.09.019
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00