Perspectives of the European Association of Nuclear Medicine (EANM) on early perfusion imaging in the context of amyloid PET imaging protocols
Early perfusion amyloid-PET imaging is emerging as a valuable tool to potentially capture patients’ neurodegeneration patterns, allowing same-day, same-tracer categorization of both amyloidosis (A) and neurodegeneration (N) biomarkers. Early perfusion amyloid-PET might provide an added value for differential diagnosis and, in keeping with the capability of FDG-PET to indirectly track co-pathology in AD patients, it may complement the information provided by amyloid PET thus supporting a more accurate weighting of the different underlying pathological processes. Early perfusion imaging is, at the moment, still a research tool, as high-level evidence regarding a non-inferiority with respect to FDG-PET (especially in MCI patients) is still not available due to the lack of dedicated clinical trials. The present paper states the position of EANM on early perfusion imaging in the framework of dual-point amyloid-PET studies. The mounting evidence for its use, as well as unmet needs and potential cost-effectiveness, are summarized and discussed with the aim of paving the path for a proper recognition of its added value in the AT(N) system and in the clinical setting to further support differential diagnosis.
Authors
- Eric Guedj
- Tatjana Traub‐Weidinger (ORCID: https://orcid.org/0000-0003-1118-926X)
- Pablo Aguiar Fernandez
- Henryk Barthel (ORCID: https://orcid.org/0000-0002-9322-9167)
- Francesco Fraioli (ORCID: https://orcid.org/0000-0003-0821-6327)
- Valentina Garibotto (ORCID: https://orcid.org/0000-0003-2422-698X)
- Nathalie L. Albert (ORCID: https://orcid.org/0000-0003-0953-7624)
- Diego Cecchin (ORCID: https://orcid.org/0000-0001-7956-1924)
- Matthias Brendel (ORCID: https://orcid.org/0000-0002-9247-2843)
- Igor Yakushev (ORCID: https://orcid.org/0000-0003-4764-798X)
- Bart van Berckel
- Donatienne Van Weehaeghe
- Silvia Daniela Morbelli (ORCID: https://orcid.org/0000-0002-7833-6095)
- Nelleke Tolboom (ORCID: https://orcid.org/0000-0002-8005-2833)
- Antoine Verger (ORCID: https://orcid.org/0000-0003-2194-0328)
Institutions
- University of Geneva (CH)
- Centre National de la Recherche Scientifique (FR)
- University of Padua (IT)
- Inserm (FR)
- Ghent University Hospital (BE)
- German Center for Neurodegenerative Diseases (DE)
- TUM Klinikum (DE)
- University Medical Center Utrecht (NL)
- Donauspital (AT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Städtisches Klinikum Dessau (DE)
- University Hospital of Geneva (CH)
- Amsterdam Neuroscience (NL)
- Munich Cluster for Systems Neurology (DE)
- Imagerie Adaptative Diagnostique et Interventionnelle (FR)
- Institut Fresnel (FR)
- Centre d'Imagerie BioMedicale (CH)
- Centrale Méditerranée (FR)
- University College London (GB)
- University of Turin (IT)
- Technical University of Munich (DE)
- Medical University of Vienna (AT)
- Ludwig-Maximilians-Universität München (DE)
- Vrije Universiteit Amsterdam (NL)
- Université de Lorraine (FR)
- Leipzig University (DE)
Publication Details
- Journal
- The EANM Journal
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.eanmj.2025.100005
- Citations
- 2
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72