Diagnostic significance of fluorine-18-fluorodeoxyglucose-positron emission tomography/computed tomography in differentiating Edmondson grade II and III hepatocellular carcinoma
<sup>18</sup>F-FDG PET/CT-derived metabolic parameters, particularly SUV<sub>max</sub>, SUV<sub>mean</sub>, TNR, TBR, and TLG, are valuable in differentiating Edmondson grade II and III HCC, with SUV<sub>max</sub> showing the optimal differential diagnostic efficacy. TLG is a three-dimensional volumetric parameter that holds some differential diagnostic potential, but it fails to display a distinct advantage. Moreover, increased <sup>18</sup>F-FDG uptake and Ki67 expression in tumor tissue correlate with poorer HCC prognoses, emphasizing their potential role in prognostic assessments.
Authors
- Fang-Fang Chao
- Xiaoli Mei
- Xing-Min Han
- Yanpeng Li (ORCID: https://orcid.org/0000-0002-0643-4809)
- Ruihua Wang (ORCID: https://orcid.org/0000-0002-4020-8039)
- Xiaobo Niu
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Surgery
- Published
- 2025-09-23
- DOI
- https://doi.org/10.4240/wjgs.v17.i9.107301
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32