Effect of the Arg16Gly β <sub>2</sub> ‐Adrenergic Receptor Polymorphism on Long‐Term Mepolizumab Response and Clinical Remission in Severe Eosinophilic Asthma: A Genotype‐Stratified, Multicenter Study
The Arg16 allele of the rs1042713 polymorphism increases the risk of severe eosinophilic asthma and may reduce the long-term efficacy of mepolizumab, whereas the Gly16 allele appears to confer better outcomes and higher remission rates.
Authors
- Nunzio Crimi (ORCID: https://orcid.org/0000-0002-8591-4535)
- Claudio Candia (ORCID: https://orcid.org/0000-0002-5888-8781)
- Maria Pia Foschino Barbaro (ORCID: https://orcid.org/0000-0001-9939-2697)
- Andrea Portacci (ORCID: https://orcid.org/0000-0002-6127-2486)
- Alessandro Saglia
- Carlo Vancheri (ORCID: https://orcid.org/0000-0002-5120-9926)
- Girolamo Pelaia (ORCID: https://orcid.org/0000-0001-9288-8913)
- Raffaele Campisi (ORCID: https://orcid.org/0000-0001-9305-6748)
- Giulia Scioscia (ORCID: https://orcid.org/0000-0002-2667-077X)
- Claudia Crimi (ORCID: https://orcid.org/0000-0002-9088-5214)
- Corrado Pelaia (ORCID: https://orcid.org/0000-0002-4236-7367)
- Santi Nolasco (ORCID: https://orcid.org/0000-0003-3995-7662)
- Vitaliano Nicola Quaranta (ORCID: https://orcid.org/0000-0001-9920-780X)
- Angelantonio Maglio (ORCID: https://orcid.org/0000-0003-1874-1686)
- Giovanna Elisiana Carpagnano (ORCID: https://orcid.org/0000-0001-7931-4704)
- Evelina Fagone (ORCID: https://orcid.org/0000-0001-8413-7300)
- Alessandro Vatrella (ORCID: https://orcid.org/0000-0001-8265-3037)
- Isabella Carrieri
- Maria D'Amato
Institutions
- University of Foggia (IT)
- University of Salerno (IT)
- Marconi University (IT)
- Magna Graecia University (IT)
- University of Catania (IT)
- Federico II University Hospital (IT)
- University of Bari Aldo Moro (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Allergy
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1111/all.70071
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16