Enzyme-responsive liposomes target endoplasmic reticulum stress-mediated apoptosis for rheumatoid arthritis therapy
CLT-FELipos represents a novel drug delivery system that specifically targets FLS and ER, which enhances CLT's therapeutic index in RA by inducing apoptosis in hyperplastic FLSs. The dual-targeting strategy (FAP-α/CD44 for FLSs and KDEL for ER) ensures precise drug delivery while reducing inflammation and joint destruction with improved safety. This innovative approach holds potential for RA treatment and warrants further clinical investigation.
Authors
- Yingying Hou (ORCID: https://orcid.org/0009-0001-0561-5835)
- C. D. Qian (ORCID: https://orcid.org/0009-0005-6671-6866)
- Huaiyu Su
- Li Chen (ORCID: https://orcid.org/0000-0003-4307-0896)
- Chenglong Li (ORCID: https://orcid.org/0000-0001-8171-6227)
- Jie Zhang (ORCID: https://orcid.org/0000-0003-2423-0006)
- Ya Huang (ORCID: https://orcid.org/0000-0002-5314-4767)
- Xiaoping Zhao (ORCID: https://orcid.org/0009-0009-1500-696X)
Institutions
- University of Electronic Science and Technology of China (CN)
- Deyang Stomatological Hospital (CN)
- Sichuan Cancer Hospital (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.phymed.2025.157299
- Citations
- 2
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.61