Branched-Chain Amino Acids Accumulate and Glutamate Decreases in Cerebral Interstitial Fluid Following Cardiopulmonary Bypass in Neonatal Swine
Following continuous CPB, BCAAs increase and glutamate decreases in extracellular CIF. Further investigations are warranted to elucidate how CPB and various neuroprotection strategies affect regional and cell type-specific changes in cerebral metabolism during critical periods of neurodevelopment.
Authors
- Zoltan Pierre Arany (ORCID: https://orcid.org/0000-0003-1368-2453)
- Kimberly L. Fiock (ORCID: https://orcid.org/0000-0002-5376-1589)
- James William Gaynor (ORCID: https://orcid.org/0000-0001-7955-5604)
- Clarissa Shoffler (ORCID: https://orcid.org/0000-0002-9064-2378)
- Todd J. Kilbaugh (ORCID: https://orcid.org/0000-0002-4959-3092)
- Marco M. Hefti (ORCID: https://orcid.org/0000-0002-3127-4528)
- Michael Noji (ORCID: https://orcid.org/0000-0002-6996-5367)
- Danielle Aronowitz (ORCID: https://orcid.org/0000-0003-0043-8558)
- Marc Yudkoff (ORCID: https://orcid.org/0000-0002-9628-9608)
- Rinat Degani (ORCID: https://orcid.org/0000-0001-5785-3766)
- Richard Melchior (ORCID: https://orcid.org/0000-0001-6855-2774)
- Christopher Petucci
- Michael A. Catalano (ORCID: https://orcid.org/0000-0001-8656-6352)
- Constantine Mavroudis (ORCID: https://orcid.org/0009-0003-6773-7939)
- Benjamin Smood (ORCID: https://orcid.org/0000-0002-8667-6591)
- Dina Abbasian
Institutions
- University of Iowa (US)
- University City Science Center (US)
- Children's Hospital of Philadelphia (US)
- Cardiovascular Institute Hospital (JP)
- University Orthopedics Center (US)
- University of Pennsylvania (US)
- Resuscitation Council (GB)
- The University of Texas at Austin (US)
Publication Details
- Journal
- European Journal of Cardio-Thoracic Surgery
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1093/ejcts/ezaf311
- Citations
- 1
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 1.32