Familial aggregation of primary hyperparathyroidism and malignancy – nationwide case-control and cohort study
This study highlights a significant familial aggregation of PHPT, particularly in early-onset cases. Although a modest overrepresentation of a family history of malignancy was observed, this may reflect multiple comparisons and surveillance bias rather than a true causal link between PHPT and cancer.
Authors
- Fredrik Granath
- Jan Zedenius (ORCID: https://orcid.org/0000-0003-2833-3758)
- Robert Bränström (ORCID: https://orcid.org/0000-0001-6245-7223)
- David Thorsteinsson (ORCID: https://orcid.org/0009-0004-1043-1733)
- Inga‐Lena Nilsson (ORCID: https://orcid.org/0000-0002-8966-3729)
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Journal of the Endocrine Society
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1210/jendso/bvaf152
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Karolinska Institutet