Bifidobacterium adolescentis CCFM1447 effectively alleviates osteoporosis by enriching intestinal flora capable of vitamin D conversion

We identify <i>Bifidobacterium adolescentis</i> CCFM1447 for its capacity to elevate VD metabolite levels within fermented supernatants. It significantly elevated serum concentrations of 1,25-dihydroxyvitamin D. Furthermore, this intervention improved bone microarchitecture, evidenced by increased trabecular number and bone volume fraction. In addition, the intestinal flora of the osteoporotic mice was disturbed. CCFM1447 intervention increased the relative abundance of beneficial bacteria such as <i>Adlercreutzia equolifaciens</i>, <i>Akkermansia muciniphila</i> and <i>Pediococcus acidilactici</i>. And it is enriched with a part of strains that have the ability to transform VD such as Enterococcus faecalis and Pediococcus acidilactici. The above results suggest that <i>B. adolescentis</i> CCFM1447 may alleviate retinoic acid-induced osteoporosis symptoms by modulating the intestinal flora and increasing the level of active vitamin D.

Authors

Institutions

Publication Details

Journal
Frontiers in Nutrition
Published
2025-09-23
DOI
https://doi.org/10.3389/fnut.2025.1647671
Citations
1
Primary Topic
Vitamin D Research Studies
Type
article
Field-Weighted Citation Impact
1.47

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Bifidobacterium adolescentis CCFM1447 effectively alleviates osteoporosis by enriching intestinal flora capable of vitamin D conversion

Liuruolan Li, Hongchao Wang, Xijie Yu, Shi Shou Lu et al.
1 citations
Frontiers in Nutrition
Vitamin D Research Studies
1.47
article

Bifidobacterium adolescentis CCFM1447 effectively alleviates osteoporosis by enriching intestinal flora capable of vitamin D conversion

Liuruolan Li, Hongchao Wang, Xijie Yu, Shi Shou Lu, Liming Huang, Yuhao Zhao, Gao Tian, Wenwei Lu, Yi Wang, Feng Ling, Yurong Zhao, H.C. Fang
article en
1 citations

Abstract

We identify <i>Bifidobacterium adolescentis</i> CCFM1447 for its capacity to elevate VD metabolite levels within fermented supernatants. It significantly elevated serum concentrations of 1,25-dihydroxyvitamin D. Furthermore, this intervention improved bone microarchitecture, evidenced by increased trabecular number and bone volume fraction. In addition, the intestinal flora of the osteoporotic mice was disturbed. CCFM1447 intervention increased the relative abundance of beneficial bacteria such as <i>Adlercreutzia equolifaciens</i>, <i>Akkermansia muciniphila</i> and <i>Pediococcus acidilactici</i>. And it is enriched with a part of strains that have the ability to transform VD such as Enterococcus faecalis and Pediococcus acidilactici. The above results suggest that <i>B. adolescentis</i> CCFM1447 may alleviate retinoic acid-induced osteoporosis symptoms by modulating the intestinal flora and increasing the level of active vitamin D.

Frontiers in NutritionVol. 12
Jiangnan University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), China National Pharmaceutical Group Corporation (China) (CN), China National Center for Food Safety Risk Assessment (CN), State Key Laboratory of Food Science and Technology (CN), Wuxi People's Hospital (CN), Xiamen Maternal and Child Health Hospital (CN), Nanjing Medical University (CN)
National Key Research and Development Program of China
Openalex Percentile: Top 15%
Vitamin D Research Studies
1.47
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.