All roads lead to TDP43: Convergent mechanisms of TDP43 autoregulation
TDP43 is an essential RNA-binding protein with fundamental ties to neurodegenerative disorders. In this issue, Hasegawa-Ogawa and colleagues (https://doi.org/10.1083/jcb.202406097) describe a new mechanism for regulating TDP43 function, involving alternatively spliced variants that inhibit TDP43 via dominant-negative activity.
Authors
- Sami J. Barmada (ORCID: https://orcid.org/0000-0002-9604-968X)
- Morgan R. Miller (ORCID: https://orcid.org/0000-0002-3740-8144)
Institutions
- University of Michigan (US)
- Michigan Medicine (US)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1083/jcb.202508101
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Institutes of Health