Invasive validation of novel 1D models for computation of coronary fractional flow reserve
1D models of vFFR facilitate rapid in-silico assessment of epicardial lesion severity. Inclusion of anatomical side branch flow mildly improved agreement, but the additional inclusion of simulated pressure was not beneficial. Agreement of 1D models was comparable to 3D simulations. However, current 1D models are not sufficiently accurate to suggest they may entirely replace wire-based assessment.
Authors
- Pim A.L. Tonino (ORCID: https://orcid.org/0000-0002-2099-5426)
- Krzysztof Czechowicz (ORCID: https://orcid.org/0000-0002-0605-8591)
- Ian Halliday (ORCID: https://orcid.org/0000-0003-1840-6132)
- Julian Gunn (ORCID: https://orcid.org/0000-0003-0028-3226)
- Danielle Keulards (ORCID: https://orcid.org/0000-0002-0913-4967)
- Eron Yones (ORCID: https://orcid.org/0009-0001-9925-227X)
- Rod Hose
- Louise Aubinière-Robb (ORCID: https://orcid.org/0000-0002-6892-1119)
- Thiruni Adikari
- Harry Saxton (ORCID: https://orcid.org/0000-0001-7433-6154)
- Tom Newman (ORCID: https://orcid.org/0000-0002-7987-9948)
- Rebecca Gosling (ORCID: https://orcid.org/0000-0001-7465-3563)
- Andrew Narracott (ORCID: https://orcid.org/0000-0002-3068-6192)
- Xu Xu (ORCID: https://orcid.org/0000-0002-9721-9054)
- Paul Morris (ORCID: https://orcid.org/0000-0002-3965-121X)
- Daniel James Taylor (ORCID: https://orcid.org/0000-0003-1068-1236)
- Marcel van’t Veer
Institutions
- Radboud University Nijmegen (NL)
- Catharina Ziekenhuis (NL)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- King's College Hospital NHS Foundation Trust (GB)
- Kingston Hospital (GB)
- Insigneo (GB)
- Eindhoven University of Technology (NL)
- University of Sheffield (GB)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1093/cvr/cvaf168
- Citations
- 4
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- National Institute for Health and Care Research
- NIHR Sheffield Biomedical Research Centre