Analytical expression of the β coefficient of cell survival curves predicted by the NanOx model in the low‐energy range

We derived in this work an analytical expression for the fast calculation of the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:semantics><mml:mi>β</mml:mi> <mml:annotation>$\beta$</mml:annotation></mml:semantics> </mml:math> coefficient for ion irradiations. Although the analytical expression resulted from the NanOx model, it can be also applied to any model used to compute <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:semantics><mml:mi>α</mml:mi> <mml:annotation>$\alpha$</mml:annotation></mml:semantics> </mml:math> . Overall, the approach presented in this work may provide a reasonable description of the behavior of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:semantics><mml:mi>β</mml:mi> <mml:annotation>$\beta$</mml:annotation></mml:semantics> </mml:math> with LET despite the large spread observed in experimental data.

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Journal
Medical Physics
Published
2025-09-23
DOI
https://doi.org/10.1002/mp.70008
Primary Topic
Radiation Therapy and Dosimetry
Type
article
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article

Analytical expression of the β coefficient of cell survival curves predicted by the NanOx model in the low‐energy range

Michaël Beuve, Étienne Testa, Mario Alcocer‐Ávila
Medical Physics
Radiation Therapy and Dosimetry
article

Analytical expression of the β coefficient of cell survival curves predicted by the NanOx model in the low‐energy range

Michaël Beuve, Étienne Testa, Mario Alcocer‐Ávila
article en

Abstract

We derived in this work an analytical expression for the fast calculation of the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:semantics><mml:mi>β</mml:mi> <mml:annotation>$\beta$</mml:annotation></mml:semantics> </mml:math> coefficient for ion irradiations. Although the analytical expression resulted from the NanOx model, it can be also applied to any model used to compute <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:semantics><mml:mi>α</mml:mi> <mml:annotation>$\alpha$</mml:annotation></mml:semantics> </mml:math> . Overall, the approach presented in this work may provide a reasonable description of the behavior of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:semantics><mml:mi>β</mml:mi> <mml:annotation>$\beta$</mml:annotation></mml:semantics> </mml:math> with LET despite the large spread observed in experimental data.

Medical PhysicsVol. 52(10)
Université Claude Bernard Lyon 1 (FR), Centre National de la Recherche Scientifique (FR)
Openalex Percentile: Top 63%
Radiation Therapy and Dosimetry
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Analytical expression of the β coefficient of cell survival curves predicted by the NanOx model in the low‐energy range — Michaël Beuve, Étienne Testa, et al. · Medical Physics (2025) | TGRS Research Map | TGRS