Neuromelanin-Sensitive MRI Contrast and Chronic Depression in Young Women
In this cohort study of young women, chronic depression was associated with reduced NM-MRI contrast, consistent with cumulative mesolimbic dopamine hypofunction. NM-MRI contrast findings were normal in young women with nonchronic depression. These findings support the importance of distinguishing between chronic and nonchronic forms of illness in parsing the heterogeneity of depressive disorders, and they suggest that low dopamine may play a role in the etiopathophysiology of chronic depression.
Authors
- Kenneth Wengler (ORCID: https://orcid.org/0000-0002-8153-5183)
- Roman Kotov
- Guillermo Horga (ORCID: https://orcid.org/0000-0002-9049-9786)
- Anissa Abi‐Dargham (ORCID: https://orcid.org/0000-0002-5039-5069)
- Greg Perlman (ORCID: https://orcid.org/0000-0001-9992-4278)
- Scott J. Moeller (ORCID: https://orcid.org/0000-0002-4449-0844)
- D Klein
Institutions
- New York Psychoanalytic Society and Institute (US)
- Stony Brook School (US)
- New York State Psychiatric Institute
- Stony Brook University (US)
- Columbia University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.33339
- Citations
- 1
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36