Comparative analysis of neutralization assays performed using live SARS-CoV-2 virus and pseudovirus to assess immunogenicity of a bivalent SARS-CoV-2 protein vaccine in humans
Our findings demonstrate a strong correlation between PVNA and LVNA results, supporting PVNA as a safe, scalable, and reliable surrogate for LVNA in evaluating vaccine immunogenicity.
Authors
- Liangzhi Xie (ORCID: https://orcid.org/0000-0003-4504-7622)
- Adam Abdul Hakeem Baidoo
- Jing Li (ORCID: https://orcid.org/0000-0002-2037-5817)
- Qiang Zhou (ORCID: https://orcid.org/0009-0008-9544-9359)
- Jian Li (ORCID: https://orcid.org/0000-0001-9434-7803)
- Dongyang Li (ORCID: https://orcid.org/0000-0002-6317-7853)
- Cuige Gao
- Dongfang Liu (ORCID: https://orcid.org/0000-0002-7295-8088)
- Jiang Yi
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Sinocelltech Group (China) (CN)
- Sino Biological (China) (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1650083
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China
- Beijing Science and Technology Planning Project