Catch-Up of Routine School-Based Immunizations Since the COVID-19 Pandemic: 4-Year Observational Cohort Study

Abstract Background School-based immunization programs (SBIPs) have been widely used to efficiently deliver vaccines to children and adolescents, achieving higher and more equitable coverage than community-based approaches, though implementation varies across regions. However, the COVID-19 pandemic disrupted SBIPs, leading to significant declines in vaccine coverage and highlighting the need for long-term assessments to determine the effectiveness of recovery efforts, especially as current research has largely overlooked SBIPs or focused narrowly on select vaccines. Objective This study aimed to assess the impact of the COVID-19 pandemic and ongoing catch-up immunization efforts on vaccine coverage and administration volume among school-aged children in the Canadian province of Alberta. We also sought to determine the magnitude of any remaining vaccine deficits and estimate the duration of additional catch-up efforts required to address those deficits. Methods In this retrospective cohort study, we used population-wide administrative health data to calculate monthly cumulative vaccine coverage among Grade 1, 6, and 9 cohorts, comparing four pandemic cohorts (2019‐2020, 2020‐2021, 2021‐2022, and 2022‐2023 grade-years) to a prepandemic cohort for each grade. We also calculated vaccine administration rates as monthly count of vaccines delivered, stratified by routine (ie, received during the school year as scheduled) and catch-up (ie, received after the regularly scheduled school year) doses. For each vaccine, we calculated vaccine coverage deficits remaining at the end of the study period and estimated time to clear those deficits based on observed catch-up uptake rates. Results All Grade 6 pandemic cohorts had lower human papillomavirus (HPV) and hepatitis B vaccine coverage at the end of the school year (2.6‐60 percentage points lower and 1.2‐41.7 percentage points lower, respectively), though coverage had increased to near prepandemic levels after approximately 3 years of follow-up. Coverage among the Grade 1 and 9 cohorts remained below prepandemic levels at study end; the largest deficits were noted in the 2022‐2023 Grade 1 cohort (7.87 percentage points lower for measles-containing vaccines, 4.64 percentage points lower for pertussis-containing vaccines) and the 2020‐2021 cohort for Grade 9 (14.0 percentage points lower for meningococcal conjugate ACYW-135 vaccine, 12.9 percentage points lower for pertussis-containing vaccines). The additional catch-up time required to reach prepandemic coverage levels for all cohorts was estimated to be less than 1 year for Grade 6 cohorts, 5.6 years for Grade 1 cohorts, and 4.8 years for Grade 9 cohorts. Conclusions Partial recovery of vaccine coverage was found for cohorts impacted by interruptions to school-based programming during the COVID-19 pandemic. Further efforts to alleviate coverage deficits among Grade 1 cohorts may be addressed in routine Grade 6 programs, while targeted efforts in postsecondary institutions may be required to address delays in Grade 9 immunizations.